ETP46464
ETP-46464
CAS: 1345675-02-6
Molecular Formula: C30H22N4O2
ETP46464 - Names and Identifiers
ETP46464 - Physico-chemical Properties
| Molecular Formula | C30H22N4O2 |
| Molar Mass | 470.52 |
| Density | 1.310±0.06 g/cm3(Predicted) |
| Boling Point | 709.3±60.0 °C(Predicted) |
| pKa | 5.10±0.20(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | ETP-46464 almost completely inhibited ATR activity at 100nM. ETP-46464 inhibited the activity of PI3Kα,mTOR and DNA-PKcs proteins with IC50 values of 170,0.6 and 36 nM, respectively. ETP-46464 can promote the breakage of the replication fork stagnation. ETP-46464 results in massive DNA damage in replicating cells. 1 μm ETP-46464 inhibits the appearance of the G2 / M phase checkpoint induced by ionizing radiation and leads to the presence of micronuclei or completely broken nuclei in the cell. ETP-46464 is especially toxic to p53-deficient cells, which is exacerbated by conditions created by replication stress, such as cyclin E expression. ETP-46464 almost completely inhibited ATR activity at 100nM. ETP-46464 inhibited the activity of PI3Kα,mTOR and DNA-PKcs proteins with IC50 values of 170,0.6 and 36 nM, respectively. ETP-46464 can promote the breakage of the replication fork stagnation. ETP-46464 results in massive DNA damage in replicating cells. 1 μm ETP-46464 inhibits the appearance of the G2 / M phase checkpoint induced by ionizing radiation and leads to the presence of micronuclei or completely broken nuclei in the cell. ETP-46464 is especially toxic to p53-deficient cells, which is exacerbated by conditions created by replication stress, such as cyclin E expression. |
ETP46464 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.125 ml | 10.627 ml | 21.253 ml |
| 5 mM | 0.425 ml | 2.125 ml | 4.251 ml |
| 10 mM | 0.213 ml | 1.063 ml | 2.125 ml |
| 5 mM | 0.043 ml | 0.213 ml | 0.425 ml |
Last Update：2024-01-02 23:10:35
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Product Name: ETP-46464 Visit Supplier Webpage Request for quotationCAS: 1345675-02-6
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Email: product@acmec-e.com
Mobile: +86-18621343501
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Product Name: ETP-46464 Visit Supplier Webpage Request for quotationCAS: 1345675-02-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: ETP-46464 Visit Supplier Webpage Request for quotation
CAS: 1345675-02-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1345675-02-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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